Cisplatin binding protein

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August undefined, 2024

WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of … WebThe protein binding rates (PBR) of platinum-containing agents cisplatin (CDDP), carboplatin (CBDCA) and oxaliplatin (L-OHP) have been reported as 98%, 25-50% and 98%, respectively. To investigate the protein-binding properties of albumin with cisplatin, carboplatin and oxaliplatin, inductively coupl …

Targeted therapy for cisplatin‐resistant lung cancer via …

WebCisplatin-bound DNA impairs the normal functions of proteins involved in DNA repair and transcription. The nucleotide excision repair (NER) process typically removes bulky abnormalities caused by chemicals or … WebAug 19, 2005 · Cisplatin is a widely used anti-tumor agent for the treatment of testicular and ovarian cancers. Carboplatin is used extensively for small cell, non small cell lung cancer … pons bulbus

Cisplatin Protein Binding Partners and Their Relevance for …

WebMar 25, 2024 · Given that apoptosis resistance is one of the causes of the cisplatin resistance of tumor cells, our aim was to determine the relationship between RRS1 and cisplatin resistance in breast cancer cells. Here, we report that RRS1 is associated with cisplatin resistance in breast cancer cells. WebMay 15, 2016 · We summarize the structural features of known cisplatin-protein adducts. • Key characteristics of the cisplatin modes of binding to proteins are described. • … WebJun 13, 2005 · Protein binding Cisplatin does not undergo instantaneous and reversible binding to plasma protein that is characteristic of normal drug-protein binding. However, the platinum itself is capable of binding to plasma proteins, including albumin, transferrin, and gamma globulin. shaolin monks uk tour

Cisplatin binding to proteins: A structural perspective

Cisplatin - Wikipedia

WebFull article: Insulin-like growth factor 2 mRNA-binding protein 2-stabilized long non-coding RNA Taurine up-regulated gene 1 (TUG1) promotes cisplatin-resistance of colorectal cancer via modulating autophagy Home All Journals Bioengineered List of Issues Volume 13, Issue 2 Insulin-like growth factor 2 mRNA-bindin .... Bioengineered WebCisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus by Umma Habiba 1,2,*, Elora Hossain 3, Aya Yanagawa-Matsuda 4, Abu Faem Mohammad Almas Chowdhury 5, Masumi Tsuda 1,6,7, Asad-uz- Zaman 2, Shinya Tanaka 1,6,7 and Fumihiro Higashino 3,4,* 1 shaolin monks xboxWebTargeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA ... /PI3K/protein kinase B (AKT) signaling pathway, resulting in decreased DDP resistance in A549/DDP cells. ... Screening and characteristics of AM binding to A549/DDP using Cell‐SELEX. Accurate targeting is the key to ... shaolin monk training camp

"WebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic … " - Cisplatin binding protein

Cisplatin binding protein

Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma …

WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the … WebAug 24, 2024 · Systematic Identification of Proteins Binding with Cisplatin in Blood by Affinity Chromatography and a Four-Dimensional Proteomic Method Authors: Jianmei Tao Shuailong Jia Huazhong University...

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WebMay 26, 2024 · Using the fluorescent cisplatin analog BODIPY-cisplatin, two-dimensional gel electrophoresis, and mass spectrometry, we identified the protein binding partners in A2780 and cisplatin-resistant A2780cis ovarian carcinoma, as well as in HCT-8 and oxaliplatin-resistant HCT-8ox colorectal cell lines. WebApr 13, 2024 · HIGHLIGHTS. who: Florentine S. B. Subtil et al. from the Department of Radiotherapy and Radiooncology, Philipps-University, Marburg, Germany have published the research: Dual PI3K/mTOR Inhibitor NVP-BEZ235 Leads to a Synergistic Enhancement of Cisplatin and Radiation in Both HPV-Negative and -Positive HNSCC Cell Lines, in the …

WebJun 3, 2013 · To identify proteins that bind to cisplatin, we synthesized two different platinum-agarose conjugates, one with two amino groups and another with two chlorides attached to platinum that are available for … WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …

WebJun 20, 2024 · Cisplatin [ cis- diamminedichloroplatinum (II) ( cis -DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its …

Web14 hours ago · The EV surface proteins as well as their expression in cells were analyzed with western blots. For the EV surface protein profiling, a coverslip coated with poly-l-lysine (PLL) to bind EVs and casein to reduce the unspecific binding of fluorescently tagged antibodies was used. The coverslip was probed with EVs and subsequently incubated …

WebMar 29, 2024 · Cisplatin binds to the copper-binding sites in the N-terminal domain of ATP7B; this binding may be an essential step of cisplatin detoxification involving copper ATPases. COX19 is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A-mediated cellular copper efflux. pons child careWebAug 2, 2016 · Our data reveal unexpected cisplatin binding sites on the protein surface that could have general significance: cisplatin fragments − [Pt (NH 3) 2 Cl] +, − [Pt (NH 3 )Cl 2 ], and − [Pt (NH 3) 2 (OH 2 )] 2+ … pons bridgeWebC-terminal binding protein‑2 (CtBP2) is a transcriptional co-repressor that is associated with tumorigenesis and tumor progression. It has been reported to predict a poor … ponsch surnameWebFeb 1, 2016 · Cisplatin owns the most tendency to plasma proteins-so that after a few hours, up to 90% of the drug is bound to protein [19, 20]. Carboplatin possesses the … shaolin monk temple near meWebCisplatin is a platinum-based drug which acts by binding to DNA by forming intrastrand cross-link conjugate which eventually leads to apoptosis due to the activation of p53, … shaolin monk training for beginnersWebMar 27, 2024 · Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus Cisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus Cancers (Basel). 2024 Mar 27;12 (4):809. doi: 10.3390/cancers12040809. Authors shaolin monk templeWeb40 rows · May 15, 2016 · Pt metalation of protein by cisplatin has been studied for a long time, but only very recently ... pons charlotte